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Identification and characterization of a new splicing variant of vascular endothelial growth factor: VEGF183.

Lei J., Jiang A., Pei D.

We report the discovery of a new splicing variant of vascular endothelial growth factor named VEGF183. It is six amino acids shorter than its closest relative, VEGF189, due to the utilization of a conserved alternate splicing donor site within exon 6a. Highly expressed in heart tissue, VEGF183 is detected in transiently transfected COS cells as 28-32-kDa monomers under reduced condition, and 46-kDa dimers under non-reduced condition - the functional unit for all VEGF isoforms.

Biochim. Biophys. Acta 1443:400-406(1998) [PubMed] [Europe PMC]

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