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UniProtKB advanced search options

Last modified January 28, 2021

The advanced search interface allows to browse the different search fields and options within the dropdown menus. There is a search box right at the top when you open the blue dropdown menu that allows you to type a concept name (e.g. "structure") and receive some autocompleted suggestions from which you can then select the most suitable one:


The table below lists the different options available in the "Advanced search" menu for the UniProt Knowledgebase. Columns 2 to 4 correspond to the submenu levels that are provided for some sections, after clicking on the (sub-)section name in the advanced search interface.

The 2-letter codes in square brackets (e.g. "[DE]", "[CC]") correspond to the line codes used in the flat text files.

UniProtKB AC
Entry name [ID]
Protein name [DE]
Gene name [GN]
Organism [OS]
Taxonomy [OC]
Virus host
Protein Existence [PE]
 Evidence at protein level
 Evidence at transcript level
 Inferred from homology
 Enzyme Classification [EC]
 Biophysicochemical properties
  Any biophysicochemical property
  Kinetic parameters
  pH dependence
  Redox potential
  Temperature dependence
 Catalytic activityEvidence type
 Activity regulationEvidence type
 Function [CC]Evidence type
  Cofactor note
  Evidence type
  Any siteEvidence type
  Active siteEvidence type
  Metal bindingEvidence type
  Binding siteEvidence type
  OtherEvidence type
 Calcium binding
 DNA binding
 Nucleotide binding
 Miscellaneous [CC]
Subcellular location
 Subcellular location [CC]Evidence type
 TransmembraneEvidence type
 Topological domainEvidence type
 IntramembraneEvidence type
Pathology & Biotech
 DiseaseEvidence type
 Allergenic propertiesEvidence type
 Toxic dose
 Biotechnological use
 Pharmaceutical use
 Disruption phenotype
 MutagenesisEvidence type
PTM / Processing
 Post-translational modification [CC]]Evidence type
 Modified residue [FT]Evidence type
 Lipidation [FT]Evidence type
 Glycosylation [FT]Evidence type
 Disulfide bond [FT]Evidence type
 Cross-link [FT]Evidence type
 Molecule Processing
  Any molecule processingEvidence type
  ChainEvidence type
  Initiator methionineEvidence type
  PeptideEvidence type
  Signal peptideEvidence type
  PropeptideEvidence type
  Transit peptideEvidence type
 Developmental stage
 InductionEvidence type
 Tissue specificity
 Binary interaction
 Subunit structureEvidence type
 3D structure available
 Secondary structure
  Any secondary structure
  Beta strand
 Mass (Da)
 Sequence length
 Alternative products
  Any alternative productEvidence type
  Alternative promoter usageEvidence type
  Alternative splicingEvidence type
  Alternative initiationEvidence type
  Ribosomal frameshiftingEvidence type
 Sequence caution
  Any sequence caution comment
  Erroneous initiation
  Erroneous termination
  Erroneous gene model prediction
  Erroneous translation
  Miscellaneous discrepancy
 Mass spectrometry
 RNA EditingEvidence type
 Natural variations
  Any natural variation
  Natural variant
  Alternative sequence
 Non-standard residueEvidence type
 Non-terminal residue
 Non-adjacent residues
 Sequence conflict
 Sequence uncertainty
 Sequence features [FT]
  Sequence complete
  Sequence incomplete
 Encoded in
  Organellar chromatophore
  Non-photosynthetic plastid
  Sequence requires processing
  Sequence is mature
 Sequence from? [RC]
Family and Domains
 Domain [FT]Evidence type
 Domain comments [CC]Evidence type
 Protein family
 Coiled-coilEvidence type
 Compositional bias
 MotifEvidence type
 RegionEvidence type
 RepeatEvidence type
 Sequence similaritiesEvidence type
 Zinc fingerEvidence type
 Any cross-reference
 Sequence databasesDatabase list
 3D structure databasesDatabase list
 Protein-protein interaction databasesDatabase list
 Chemistry databasesDatabase list
 Protein family/group databasesDatabase list
 PTM databasesDatabase list
 Genetic variation databasesDatabase list
 2D gel databasesDatabase list
 Proteomic databasesDatabase list
 Protocols and materials databasesDatabase list
 Genome annotation databasesDatabase list
 Organism-specific databasesDatabase list
 Phylogenomic databasesDatabase list
 Enzyme and pathways databasesDatabase list
 Family and domain databasesDatabase list
 Gene expression databasesDatabase list
 Other databasesDatabase list
Web resource
Date of
 Date of creation
 Date of last entry modification
 Date of last sequence modification
Gene Ontology [GO]
Small molecule
Keyword [KW]
Literature Citation
 Proteome ID
 Proteome Component
Cited for
 Not active
UniRef ID
UniParc ID
Jobs (last 7 days)
 Retrieve/ID mapping

See also:
Simple full text search
Query fields for UniProtKB
How can I query UniProtKB annotations by evidence? - A guide to evidence codes and labels in entry view and advanced search

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