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Why is UniProtKB composed of 2 sections, UniProtKB/Swiss-Prot and UniProtKB/TrEMBL?

Last modified April 10, 2018

Swiss-Prot (created in 1986) is a high quality manually annotated and non-redundant protein sequence database, which brings together experimental results, computed features and scientific conclusions. UniProtKB/Swiss-Prot is now the reviewed section of the UniProt Knowledgebase.

The TrEMBL section of UniProtKB was introduced in 1996 in response to the increased dataflow resulting from genome projects. It was already recognized at that time that the traditional time- and labour-intensive manual curation process which is the hallmark of Swiss-Prot could not be broadened to encompass all available protein sequences. UniProtKB/TrEMBL contains high quality computationally analyzed records that are enriched with automatic annotation and classification. These UniProtKB/TrEMBL unreviewed entries are kept separated from the UniProtKB/Swiss-Prot manually reviewed entries so that the high quality data of the latter is not diluted in any way. Automatic processing of the data enables the records to be made available to the public quickly.

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UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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